Scientific Advisory Board Member
Balaraman Kalyanaraman, PhD is one of the world’s experts in nitroxide-based drugs and superoxide spin traps. Dr. Kalyanaraman is currently Chairman and Professor of Department of Biophysics and Director of the Free Radical Research Center, Medical College of Wisconsin, US National Electron Spin Resonance (ESR) Laboratory.
Dr. Kalyanaraman is also Associate Director of the Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI and is distinguished as the International EPR Outstanding Researcher for Application of EPR in Biology & Medicine. He serves as an Associate Editor for Free Radicals in Biology and Medicine, Free Radical Research, and the Biochemical Journal.
Dr. Kalyanaraman's research centers on the application of ESR in free radical biology, understanding the role of free radicals in signal transduction and apoptosis, detection of free radicals by EPR spin-trapping, fluorescence, optical stopped-flow, and HPLC techniques. He also works on syntheses of mitochondrially-targeted spin traps, spin labels and ROS-specific fluorescence probes; EPR/ENDOR/NMR studies of active site geometry of redox-active enzymes (e.g. superoxide dismutase), chemotherapeutic drug (e.g. doxorubicin) toxicity and reduction of toxicity, mechanism of apoptosis in tumor cells and normal cells.
Dr. Kalyanaraman's current interest is the role of mitochondria-derived anti-oxidants in chemically-induced neurodegenerative type syndromes in animal models, mechanism of protein aggregation, proteosomal dysfunction and apoptotic neuronal cell death. This includes Oxidative Stress and apoptosis inducing cellular degeneration in cell culture and animal models; and therapeutic drug intervention of disease progression in mouse models of degenerative disease.
