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Prostate cancer is the second leading cause of cancer deaths among US men  Over 200,000 new patients are diagnosed with prostate cancer every year in the US alone  About 35,000 of these men have advanced metatstatic prostate tumor for whom there is no cure 

Resources

Oxygen Free Radicals in Prostatic Diseases:

 

1. Sikka, SC. Role of oxidative stress response elements and antioxidants in prostate cancer pathobiology and chemoprevention--a mechanistic approach. Curr. Med Chem. 2003; 10(24):2679-92.

2. Cerutti, PA. Prooxidant states and tumor promotion. Science 1985, 227: 375-381.

3. Oberley, TD and Oberley, LW. Oxygen radicals and cancer. In: Yu, BP (ed.), Free Radicals In Aging. Ann Arbor: CRC Press, 247-267, 1993.

4. Lee, WH, Morton, RA, Epstein, JD, Brooks, JD, Campbell, PA, Bova, GS, Hsieh, WS, Isaacs, WB, Nelson, WG. Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis. Proc. Natl. Acad. Sci. (USA), 1994 91:11733-37.

5. Sen, CK and Packer, L. Antioxidant and redox regulation of gene transcription. FASEB J 1996, 10:709-720.

6. Kamat AM, Lamm DL. Diet and nutrition in urologic cancer. W. V. Med. J. 2000; 96: 449-54.

7. Dargel, R. Lipid peroxidation - a common pathogenic mechanism? Exp. Toxic. Pathol. 1992, 44:169-181.

8. Kristal AR. Vitamin A, retinoids and carotenoids as chemopreventive agents for prostate cancer. J. Urol. 2004; 171(2 Pt 2):S54-8.

9. Crawford ED. Epidemiology of prostate cancer. Urology. 2003; 62(6 Suppl. 1):3-12.

10. Hwang ES, Bowen PE. Can the consumption of tomatoes or lycopene reduce cancer risk? Integr. Cancer Ther. 2002; 1:121-32.

11. Giovannucci, E, Ascherio, A, Rimm, EB, Meir, J et al. Intake of carotenoids and retinol in relation to risk of prostate cancer. J. Natl. Cancer Inst. 87(23):1767-1776, 1995.

12. Heinonen, OP, Albanes, D, Virtamo, J, Taylor, PR, Huttunen, JK, Hartman, AM, Haapakoski, J, Malila, N, Rautalahti, M, Ripatti, J, Maenpaa, H, Teerenhovi, L, Koss, L, Virolainen, M, and Edwards, BK. Prostate cancer and supplementation with α-tocopherol and β-carotene: Incidence and mortality in a controlled trial. 1998, J. Natl. Cancer Inst. 90: 440-446.

13. Clark, LC, Dalkin, B, Krongrad, A, Combs, GF, Turnbull, BW, Slate, EH, Witheringtion, R, Herlong, JH, Janosko, JE, Carpenter, D, Borosso, C, Falk, S, and Rounder, J. Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial. Br. J. Urol. 1998, 81:730-734.

14. Rautalahti, M and Huttunen, J. Antioxidants and carcinogenesis. Ann. Med. 1994, 26:435-441.
15. Ho E, Boileau TW, Bray TM. Dietary influences on endocrine-inflammatory interactions in prostate cancer development. Arch. Biochem . Biophys. 2004; 428(1):109-17.

16. Feig, DI, Reid, TM and Loeb, LA. Reactive oxygen species in tumorigenesis. Cancer Res. 1994, 54:1890s-1894s.

17. Eeles RA, Powles TJ. Chemoprevention options for BRCA1 and BRCA2 mutation carriers. J. Clin. Oncol. 2000;18(21 Suppl):93S-9S.

18. Oberley TD, Zhong W, Szweda, LI and Oberley LW. Localization of antioxidant enzymes and oxidative damage products in normal and malignant prostate epithelium. The Prostate, 2000: 44: 144-155.

19. Tam NN, Nyska A, Maronpot RR, Kissling G, Lomnitski L, Suttie A, Bakshi S, Bergman M, Grossman S, Ho SM. Differential attenuation of oxidative/nitrosative injuries in early prostatic neoplastic lesions in TRAMP mice by dietary antioxidants. Prostate. 2006; 66(1):57-69.

20. Hatziapostolou M, Polytarchou C, Katsoris P, Courty J, Papadimitriou E. Heparin affin regulatory peptide/pleiotrophin mediates fibroblast growth factor 2 stimulatory effects on human prostate cancer cells. J Biol Chem. 2006; 281(43):32217-26.

21. Tam NN, Leav I, Ho SM. Sex hormones induce direct epithelial and inflammation-mediated oxidative/nitrosative stress that favors prostatic carcinogenesis in the noble rat. Am. J. Pathol. 2007 Oct;171(4):1334-41. Epub 2007 Aug 23.

22. Attia S and Wilding G. Novel antioxidant technology for prostate cancer chemoprevention and treatment. Expert opinion on Therapeutic Patents 2006, 16 (9): 1255-1267.

 

23. Saito A, Hayashi T, Okuno S, Nishi T, Chan PH. Modulation of the Omi/HtrA2 signaling pathway after transient focal cerebral ischemia in mouse brains that overexpress SOD1. Brain Res. Mol. Brain Res. 2004 Aug 23;127(1-2):89-95.